Asian Food Science Journal

Aims: The aim of the present work is to formulate a fast dissolving nutraceutical tablet containing clove powder as drug, by direct compression method. Tablets contain super-disintegrant which disintegrate and dissolve fast and give its rapid onset of action in pain.

Place and Duration of Study: Clove (Eugenia caryophyllus) was procured from local market were collected from the local area of Bareilly region, India. The plant material were identified and authenticated by the Department of Pharmacognosy of Ram Murti Smarak College of Engineering & Technology (Pharmacy), Bareilly, India.

Methodology: The direct compression method was used for preparation of fast dissolving nutraceutical tablets containing clove. The pre-compression evaluations and the post compression evaluation of nutraceutical tablets like appearance, thickness, weight variation, hardness and friability, disintegration time, in vitro dissolution studies and drug content were evaluated.

Results: The results of all evaluation parameters of nutraceutical tablet were within the acceptable limit. The post compression evaluation of nutraceutical tablets like appearance, thickness of the tablets was found to be1.2±0.1 cm, weight variation 0.489±0.021 to 0.497±0.034, hardness 4.01±0.21 kg/cm² to 4.81±0.033 kg/cm² and friability 0.11±0.045 to 0.23±0.0.12%., disintegration time in 273±1.47 to 142±1.50 seconds and In-vitro dissolution studies and drug content were evaluated of the tablets was found to be 86.34 ±2.3 to 95.23±2.5%. It was concluded that the batch F3 formulated by using combination of crosspovidone super-disintegrant shows excellent disintegration time 142±1.50 seconds, enhance dissolution rate 95.23±2.5% and all parameter effect were found in acceptable limits.

Conclusion: The nutraceutical tablets of clove formulation containing crosspovidone have relatively faster dissolution rate and release of active medicaments which is used in dental problem and other various treatments.